By Cedar H. A. Boakye and Roger L. Kaspar
Recently, there has been an upsurge of interest in enhancing topical delivery of large biomolecules into the skin for the management of diverse dermatological disease conditions. The stratum corneum, which forms the outermost layer of the skin, prevents body water loss through the skin and is a formidable barrier to entry of foreign substances, particularly those that are charged and have a molecular mass of greater than 500.
A variety of delivery approaches, including the use of different types of lipids, peptides, permeation enhancers, sonoporation, iontophoresis, microjets, microneedles, and nanoparticles are being developed to enhance topical delivery and deposition of potential therapeutic macromolecules such as vaccines, peptides, proteins, siRNA, as well as DNA plasmids and oligonucleotides for treatment of skin conditions such as psoriasis, atopic dermatitis, acne, chronic wounds, genetic skin disorders, and skin cancer.
Nonetheless, each of these technologies falls short of attaining functional topical and transdermal drug delivery for translation to clinical trials and ultimately for FDA approval for patient use and benefit.
The FDD mini-symposium Topical Delivery of Nucleic Acid and Protein Therapeutics: Unmet Needs and Potential Applications at the 2014 AAPS Annual Meeting and Exposition will address the various challenges as well as the advances made in the topical delivery of various nucleic acids, proteins, and vaccines into the skin. At this mini-symposium, renowned researchers with cutting edge expertise in topical and transdermal delivery of macromolecules will be deliberating on the diverse strategies being utilized to augment topical delivery of siRNAs and peptides for use in dermatology therapeutics.
The speakers and their presentations include the following:
- Chad Mirkin, Ph.D., is the director of the International Institute of Nanotechnology, Northwestern University, and a member of the President’s Council of Advisors on Science & Technology (Obama Administration). He will present Spherical Nucleic Acid (SNA) Nanostructures for Advanced Wound Healing Applications.
- Samir Mitragotri, Ph.D., is a professor in chemical engineering, University of California, Santa Barbara (UCSB), and founding director of UCSB’s Center for Bioengineering. He has expertise in biomaterials and drug delivery and will share his presentation Technologies to Enable Peptides Overcome the Skin Barrier: Some New Paradigms.
- Mandip Singh, Ph.D., is a professor and department chair of pharmaceutics at Florida A&M University and has extensive expertise in nanoparticle-based delivery of nucleic acids using polymers and cationic lipids for the management of skin inflammatory diseases including psoriasis). He will be presenting Topical Delivery of Multiple Nucleic Acids in Psoriasis Treatment: Some New Targets.
Learn more about topical delivery by attending this session on Tuesday, November 4, 2 pm–4 pm, in the San Diego Convention Center Room 8. We hope to see you there!